Insitro

Insitro is a biotechnology company that integrates machine learning and high-throughput biology to redefine the process of drug discovery and development through data-driven science. Founded in 2018 by computer scientist Daphne Koller, the company is headquartered in South San Francisco, California. Insitro’s mission is to accelerate the development of more effective and accessible medicines by decoding the complexity of human diseases through the measurement and modeling of biological data.

Mission and Vision

Insitro’s mission is to harness the power of machine learning and large-scale data to deliver better medicines, faster, to the patients who need them most. Its vision is to usher in a new era of medicine guided by the convergence of human biology and artificial intelligence.

Technological Infrastructure

Insitro’s platform combines machine learning, human genetics, and quantitative biology to uncover disease mechanisms and therapeutic opportunities. The company builds in vitro human cell–derived disease models designed to improve the predictive relationship between experimental biology and clinical outcomes.

Its approach integrates:

• High-resolution cellular imaging
• Functional genomics
• Clinical data from large human cohorts

These multidimensional datasets are processed through Insitro’s machine learning algorithms to identify causal biological relationships and potential therapeutic intervention points.

The company’s automated laboratories produce high-quality, reproducible, and scalable datasets, enabling the creation of reusable data flows that feed into its AI-driven decision-support systems. These systems inform candidate selection and accelerate clinical development timelines.

Research and Development Focus

Insitro’s R&D programs are centered around three major therapeutic areas:

• Metabolism: Focused on metabolic-associated steatotic liver disease (MASLD) and obesity.
• Neuroscience: Programs addressing amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders.
• Oncology: Discovery of novel targets through integration of cellular and genetic data.

By combining high-content cellular models with clinical datasets, Insitro seeks to develop molecules with improved efficacy and translational potential. The company also extends its platform capabilities through pharmaceutical collaborations targeting additional disease domains.

Platform Architecture

Insitro’s integrated discovery platform aims to reduce uncertainty and accelerate decision-making across every stage of drug development. It consists of three main components:

1. Machine Learning–Enabled Biological Insight: AI models analyze multimodal cellular and clinical data to simulate disease states and identify relevant patterns.
2. Causal Biology Targeting: Human genetic evidence is used to reveal causal mechanisms underlying disease pathways.
3. Modular Technology Stack: Automation, data generation, and modeling processes work in concert to produce scalable and reusable datasets.

This architecture supports both Insitro’s internal discovery programs and its external partnerships with biopharmaceutical companies.

Corporate Structure and Culture

Insitro’s multidisciplinary team spans life sciences, engineering, human genetics, computational learning, and pharmaceutical research. The company fosters a collaborative and inclusive culture, emphasizing the synergy between experimental biology and computational innovation.

The company’s name and logo symbolize the integration of biology and technology: the lowercase “i” represents a human figure; its base resembles a test tube, while the hexagonal dot above signifies a carbon ring—together illustrating the continuum from biological cells to data-driven medicine.